Cover
List of Contributors
1 Multifunctionalized Ferri‐liposomes for Hyperthermia Induced Glioma Targeting and Brain Drug Delivery
1. 1.1 Introduction
2. 1.2 Liposome
3. 1.3 Experimental
4. 1.4 Liposome Synthesis
5. References
2 Biofabrication Techniques for Ceramics and Composite Bone Scaffolds
1. 2.1 Introduction
2. 2.2 Scaffolds
3. 2.3 Manufacturing Processes
4. 2.4 Conclusion
5. References
3 Developments in Hydrogel‐based Scaffolds and Bioceramics for Bone Regeneration
1. 3.1 Introduction
2. 3.2 Directions in the Design of Hydrogels for Bone Regeneration
3. 3.3 Ca/P Biomaterials for Bone Regeneration
4. 3.4 Perspectives
5. Acknowledgments
6. References
4 Zirconia‐Based Composites for Biomedical Applications
1. 4.1 Introduction
2. 4.2 Inert Ceramics for Biomedical Applications: Monolithic Al₂O₃ and ZrO₂
3. 4.3 New Approach for Biomedical Grade Ceramics: Zirconia‐Based Composites
4. 4.4 Conclusion
5. References
5 Bioceramics Derived from Marble and Sea Shells as Potential Bone Substitution Materials
1. 5.1 Introduction
2. 5.2 Biomimetic Approaches for Biomaterials Design
3. 5.3 Biogenic Precursors for Hydroxyapatite
4. 5.4 Synthesis Routes
5. 5.5 Processing of Marble and Shells‐Derived Hydroxyapatite
6. 5.6 Material Characterization
7. 5.7 In vitro Behavior
8. 5.8 Degradation in Biological Environment
9. 5.9 In vivo Performance Evaluation
10. 5.10 Conclusions
11. Acknowledgment
12. References
6 Bioglasses and Glass‐Ceramics in the Na₂O–CaO–MgO–SiO₂–P₂O₅–CaF₂ System
1. 6.1 Introduction
2. 6.2 General Technical Aspects
3. 6.3 Design of Compositions
4. 6.4 Materials and Methods
5. 6.5 Structural Features of Glasses, Devitrification, and Materials' Properties
6. 6.6 In vitro Biomineralization Ability (SBF Tests and HA Formation)
7. 6.7 Cell Culture Testing and Tissue Response
8. 6.8 Animal Testing and Clinical Tests
9. 6.9 Concluding Remarks
10. Acknowledgments
11. Bibliography
7 Electrical Functionalization and Fabrication of Nanostructured Hydroxyapatite Coatings
1. 7.1 Introduction
2. 7.2 Necessity and Prerequisites of Electrical Functionalization of Hydroxyapatite to Control Bone Cell Attachment
3. 7.3 Computed Designing of Nanostructured Hydroxyapatite Electrical Potential (Structurally Depended Functionalization)
4. 7.4 HA Clusters and Nanoparticles (NPs)
5. 7.5 Fabrication of Nanostructured Hydroxyapatite Coatings
6. 7.6 Biological Properties of the Electrically Functionalized Hydroxyapatite Coatings
7. 7.7 Biocompatibility of Nanostructured and Electrically Functionalized Hydroxyapatite Coatings: Subcutaneous Model
8. 7.8 General Conclusions
9. References
8 Bioactive Micro‐arc Calcium Phosphate Coatings on Nanostructured and Ultrafine‐Grained Bioinert Metals and Alloys
1. 8.1 Bioinert Alloys in Nanostructured and Ultrafine‐Grained States and Bioactive Calcium Phosphate Coatings for Medical Applications
2. 8.2 Production, Structure, and Mechanical Properties of Bioinert Alloys Based on Titanium and Niobium in Nanostructured and Ultrafine‐grained States
3. 8.3 Micro‐Arc Oxidation Method for the Production of Bioactive Calcium Phosphate Coatings on the Surface of Bioinert Metals and Alloys
4. 8.4 Hydrophilic Calcium Phosphate Coatings with Developed Surface Relief, Porous Morphology, and High Rate of Bioresorption
5. 8.5 Wollastonite–Calcium Phosphate Coatings with Enhanced Strength Characteristic and High Biological Activity
6. 8.6 Zn‐ or Cu‐incorporated Calcium Phosphate Coatings with Promising Antibacterial Properties
7. 8.7 Biological Studies In Vitro of Wollastonite‐, Zinc‐, and Copper‐incorporated Calcium Phosphate Coatings on Titanium and Niobium Alloys
8. 8.8 Development and Medical Applications of Dental Implants Based on Nanostructured Titanium with Calcium Phosphate Coating
9. 8.9 Conclusions
10. Acknowledgments
11. References
9 Engineering of Bioceramics‐Based Scaffold and Its Clinical Applications in Dentistry
1. 9.1 Introduction
2. References
10 Bioceramics in Endodontics
1. 10.1 Introduction
2. 10.2 Portland Cement
3. 10.3 Mineral Trioxide Aggregate (MTA)
4. 10.4 MTA Angelus
5. 10.5 OrthoMTA
6. 10.6 MTA Fillapex
7. 10.7 MTA Plus
8. 10.8 MTA Bio
9. 10.9 MTA Sealer (MTAS)
10. 10.10 E‐MTA
11. 10.11 MM‐MTA
12. 10.12 Fluoride Containing MTA Cements
13. 10.13 Nano‐modified MTA
14. 10.14 Light‐Cured MTA
15. 10.15 Endocem MTA
16. 10.16 Biodentine
17. 10.17 BioAggregate
18. 10.18 DiaRoot BioAggregate
19. 10.19 EndoSequence Root Repair Material (ERRM)
20. 10.20 iRoot BP
21. 10.21 iRoot BP Plus
22. 10.22 iRoot SP
23. 10.23 iRoot FS
24. 10.24 EndoSequence BC Sealer
25. 10.25 Ceramicrete‐D
26. 10.26 Generex A
27. 10.27 Capasio
28. 10.28 Geristore
29. 10.29 Radiopaque Dicalcium Silicate Cement (RDSC)
30. 10.30 Calcium‐enriched Mixture (CEM) Cement
31. 10.31 Calcium Silicate
32. 10.32 EndoBinder
33. 10.33 Quick‐Set
34. 10.34 Bioceramic Gutta‐percha
35. 10.35 Bioactive Glasses
36. 10.36 Cimento Endodontico Rapido (CER)
37. 10.37 Endo‐CPM Sealer
38. 10.38 ProRoot Endo Sealer
39. 10.39 Concluding Remarks
40. References
11 Extending the Concept of Hemopoietic and Stromal Niches as an Approach to Regenerative Medicine
1. 11.1 Introduction
2. 11.2 Postulated Stage (a Hypothesis) of the Niche Concept
3. 11.3 Morphofunctional Stage of the Niche Concept
4. 11.4 Topographical Stage of the Niche Concept
5. 11.5 Quantitative Stage of the Niche Concept
6. 11.6 Bioengineering Stage of the Niche Concept
7. 11.7 Concluding Remarks
8. References
12 Experimental and Pilot Clinical Study of Different Tissue‐Engineered Bone Grafts Based on Calcium Phosphate, Mesenchymal Stem Cells, and Adipose‐Derived Stromal Vascular Fraction
1. 12.1 Introduction
2. 12.2 Materials and Methods
3. 12.3 Results
4. 12.4 Discussion
5. Acknowledgments
6. References
13 Bone Substitutes in Orthopedic and Trauma Surgery
1. 13.1 Introduction
2. 13.2 Principles of Bone Grafting
3. 13.3 Causes of Bone Defects in Orthopedic Surgery
4. 13.4 Properties of Bone Substitutes
5. 13.5 Types of Bone Substitutes
6. 13.6 Choosing the Bone Graft
7. 13.7 Demineralized Bone Matrix (DBM)
8. 13.8 Bone Morphogenetic Proteins (BMPs)
9. 13.9 Calcium Phosphate and HA
10. 13.10 Bioactive Glasses
11. 13.11 Polymers‐Based Bone Graft Substitutes
12. 13.12 Bone Substitutes in Treating Bone Infections
13. 13.13 Conclusion
14. References
Index
End User License Agreement

List of Tables

Chapter 1
1. Table 1.1 Nutrient transportation pathways in the BBB.
2. Table 1.2 Major MDDSs based on CPPs combined with other drug carriers.
Chapter 2
1. Table 2.1 Hierarchical pore size distribution for an ideal scaffold.
2. Table 2.2 Materials commonly used to produce bioceramic composite scaffolds for ...
3. Table 2.3 Additive manufacturing processes classification according to theAmeric...
4. Table 2.4 Main characteristics of the additive manufacturing processes for tissu...
Chapter 4
1. Table 4.1 Biomedical application of ceramics [1–4].
2. Table 4.2 Classification and examples of ceramics according to theirin vivo beha...
3. Table 4.3 Characteristics of first‐, second‐, and third‐generation Al₂O₃ and ISO...
4. Table 4.4 Typical physical and mechanical properties of load‐bearing ceramics fo...
5. Table 4.5 Core material for the all‐ceramic dental restorations shown in Figure ...
Chapter 5
1. Table 5.1 Biogenic precursors used for the synthesis of hydroxyapatite.
2. Table 5.2 Scaffold fabrication techniques.
3. Table 5.3 Mechanical properties of HAP products [1,11,16,17,111,124,125,127,128,...
Chapter 6
1. Table 6.1 Chemical compositions of experimental glasses.
2. Table 6.2 Density and linear shrinkage of compacts made of the glass powders G‐A...
3. Table 6.3 General assignments of Raman and IR bands.
4. Table 6.4 Properties of glass‐powder compacts of G‐1, G‐2, and G‐3 heat treated ...
Chapter 7
1. Table 7.1 EP and surface charge density of calcium phosphate coatings prepared b...
2. Table 7.2 The experimental parameters for Si‐HA coating and Ti substrate.
3. Table 7.3 Subcutaneous biocompatibility of nanostructured electrically functiona...
Chapter 8
1. Table 8.1 Mechanical properties of ultrafine‐grained titanium produced after var...
2. Table 8.2 Mechanical characteristics of titanium alloys in ultrafine‐grained and...
3. Table 8.3 The free surface energy of CaP coatings on Ti and Ti–40Nb.
4. Table 8.4 Elemental composition of W‐CaP coatings produced under the voltage of ...
5. Table 8.5 The free surface energy of W–CaP coatings on Ti and Ti–40Nb.
6. Table 8.6 Elemental composition in atomic percentage of Zn–CaP and Cu–CaP coatin...
7. Table 8.7 Free surface energy of Zn–CaP and Cu–CaP coatings on Ti and Ti–40Nb.
8. Table 8.8 Potassium ion concentration in intercellular fluids and percentage of ...
9. Table 8.9 Ion concentrations and ALP activity in intercellular fluids of HLPSCs ...
10. Table 8.10 Death indices of Jurkat T cells after 24 hours of cultivation with th...
11. Table 8.11 Osteocalcin concentrations (ng/ml) in supernatants of seven‐day adipo...
Chapter 9
1. Table 9.1 Calcium phosphate ceramics with corresponding chemical formula and Ca/...
2. Table 9.2 Summary of polymers used in combination with ceramics, categorized in ...
Chapter 10
1. Table 10.1 Radiopacifiers used in endodontic bioceramics.
2. Table 10.2 Clinical application of bioceramics in vital pulp therapy.
3. Table 10.3 Clinical application of bioceramics in nonvital teeth.
Chapter 12
1. Table 12.1 Patients and tissue‐engineered bone grafts characteristics.
Chapter 13
1. Table 13.1 Bone substitutes commercial names and main characteristics.

List of Illustrations

Chapter 1
1. Figure 1.1 Transportation pathways across the BBB.
2. Figure 1.2 Cellular components of the blood–brain barrier (cross‐section view).
3. Figure 1.3 Molecular components of endothelial tight junctions.
4. Figure 1.4 Schematic drawing of a liposome.
5. Figure 1.5 Mechanisms of drug release from TTSL and the LTSL.
6. Figure 1.6 In vitro BBB model confirmation using (a) FITC‐Dextran and (b) TEER....
7. Figure 1.7 Comparison of essential junction proteins expressed by bEnd.3 cells ...
8. Figure 1.8 Material characterization. (a) Dynamic light scattering (DLS) data o...
9. Figure 1.9 DOX release over time: (a) DOX release data from different liposome ...
10. Figure 1.10 Permeability of the ferri‐liposomes across the BBB model. Data are ...
Chapter 2
1. Figure 2.1 Variation of bone elastic modulus and yield strain as a function of ...
2. Figure 2.2 Interactions between bone and the scaffold surface at different topo...
3. Figure 2.3 μCT image of a PCL‐HA scaffold.
4. Figure 2.4 Young's modulus versus strength for different materials.
5. Figure 2.5 Porous composite scaffold of different inner structure designs produ...
6. Figure 2.6 (A) Schematic representation of the rapid direct deposition of ceram...
7. Figure 2.7 Schematic representation of the robocasting process.
8. Figure 2.8 SEM micrographs of a TCP scaffold: (a) general view. (b) XY plane vi...
9. Figure 2.9 β‐TCP/collagen scaffold built through vat‐photopolymerization and ge...
10. Figure 2.10 Schematic diagrams of the scaffold and the proposed implantation.
11. Figure 2.11 (a) Mould built by vat‐photopolymerization and respective sintered ...
12. Figure 2.12 Stereo‐thermal‐lithography system.
13. Figure 2.13 EDS and SEM micrograph of PEGDMA/HA hydrogel scaffolds.
14. Figure 2.14 Composite scaffolds containing 50% of β‐TCP and 50% PDLLA.
15. Figure 2.15 Commercial β‐TCP implant (a) and PCL/TCP scaffolds built by SLS (b)...
16. Figure 2.16 SEM micrograph of sintered layer's surface with irradiated at 1200 ...
17. Figure 2.17 (a) Effect of degradation tests and cell culturing on the compressi...
18. Figure 2.18 Alamar blue assay for different scaffold compositions after 7, 14, ...
19. Figure 2.19 Morphology of SaOS‐2 cells cultured on different scaffolds for 7 da...
20. Figure 2.20 (a) SEM image of PLLA/CHA nanocomposite microspheres. (b) PLLA/CHA ...
Chapter 3
1. Figure 3.1 Hydrogels with properties controlled by the nature and length of the...
2. Figure 3.2 Hydrogel formation by (a) cross‐linking of macromolecules; (b) polym...
3. Figure 3.3 (a) Schematic representation of osteoblasts anchored on nanostructur...
4. Figure 3.4 (a) μ‐CT analysis of a rabbit femoral condyle grafted with β‐TCP gra...
5. Figure 3.5 A wedge for tibial osteotomy prepared with HA and β‐TCP by laser sin...
6. Figure 3.6 Preparation of blocks of β‐TCP by the polyurethane foam method. (a) ...
7. Figure 3.7 (a) SEM of a β‐TCP granule prepared with 25 g Ca/P powder in the slu...
8. Figure 3.8 (a) Influence of increasing the concentration of β‐TCP in the slurry...
9. Figure 3.9 Vector analysis of the stacks of β‐TCP granules illustrated in Figur...
Chapter 4
1. Figure 4.1 Grain size distribution as retrieved from Al₂O₃ femoral heads belong...
2. Figure 4.2 Field emission scanning electron microscopy (FESEM) micrograph of ...
3. Figure 4.3 Scheme of crack growth rate–stress intensity behavior and determinat...
4. Figure 4.4 Schematic representation of the microstructures of the main types of...
5. Figure 4.5 Schematic illustration of stress‐induced phase transformation toughe...
6. Figure 4.6 Schematic representation of how a partial transformation of t‐ZrO₂ g...
7. Figure 4.7 Scanning electron microscopy (SEM) micrograph of Al₂O₃–5 vol% ZrO₂ c...
8. Figure 4.8 Crack velocity versus stress intensity factor (K_I) for biomedical gr...
9. Figure 4.9 Aging kinetics (monoclinic fraction increase versus time at 134 °C, ...
10. Figure 4.10 (a) Monoclinic ZrO₂ profiles acquired by micro‐Raman spectroscopy o...
11. Figure 4.11 Atomic force microscopy (AFM) images of (a) 3Y‐TZP, (b) ATZ, and ...
12. Figure 4.12 Aging behavior (a) and mean flexural strength (b) of 3Y‐TZP, ATZ, a...
13. Figure 4.13 Gas phase condensation of Al₂O₃/ZrO₂ hybrid nanoparticles prepared ...
14. Figure 4.14 SEM micrographs of ATZ‐sintered composites derived (a) by the gas c...
15. Figure 4.15 TEM micrograph of 12Ce‐TZP/30 vol% Al₂O₃ sintered at 1500 °C for tw...
16. Figure 4.16 Fracture strength (a) and volume fraction of the monoclinic phase o...
17. Figure 4.17 Relation between fracture toughness and biaxial flexure strength fo...
18. Figure 4.18 Biaxial flexure strength (a) and m‐ZrO₂ content (b) of Ce‐TZP/Al₂O₃
19. Figure 4.19 V–K_I curves of Ce‐TZP/Al₂O₃ nanocomposite as compared to those of m...
20. Figure 4.20 Strength–toughness relationships for Ce‐TZP (squares), Ce‐TZP/Al₂O₃
21. Figure 4.21 TEM image (a) and chemical composition (at%) on the A, B, and C gra...
22. Figure 4.22 Crack propagation in (a) 12Ce‐TZP/30 vol% Al₂O₃ (12Ce‐30A), (b) 12C...
23. Figure 4.23 (a) Synthesized porous ZrO₂/HA scaffold with 91 ± 2.8% porosity. (b...
24. Figure 4.24 SEM images of adhered cells on scaffold. Three days after cell seed...
Chapter 5
1. Figure 5.1 Processing steps for hydroxyapatite synthesis by thermal decompositi...
2. Figure 5.2 Processing steps for hydroxyapatite synthesis by thermal decompositi...
3. Figure 5.3 Derived hydroxyapatite processed by cold pressing and scaffolding te...
Chapter 6
1. Figure 6.1 Thermal analysis (dilatometry top curves and DTA bottom curves) of G...
2. Figure 6.2 Akermanite predominantly forms at ≥700 °C (JCPDS card of akermanite‐...
3. Figure 6.3 Characteristic microstructure of G‐A1 glass‐ceramics after heat trea...
4. Figure 6.4 Weibull statistics of flexural strength (three‐point bending) of gla...
5. Figure 6.5 Microstructure of interfaces developed between G‐A1 glass‐ceramic (u...
6. Figure 6.6 Phase separation occurred in the investigated annealed bulk glasses ...
7. Figure 6.7 Raman spectra of the investigated glasses, obtained from the surface...
8. Figure 6.8 FT‐IR spectra of the investigated glasses. The spectrum of crystalli...
9. Figure 6.9 Thermal analysis of Al‐free glasses G‐1, G‐2, G‐3, and G‐1b, and the...
10. Figure 6.10 Evolution of the microstructure of the annealed bulk glass G‐1 afte...
11. Figure 6.11 X‐ray diffractograms of the glass‐powder compacts from the Al‐free ...
12. Figure 6.12 Typical microstructures of glass‐powder compacts made of the compos...
13. Figure 6.13 Calculated spectrum “(G‐1d)‐(G‐1e)” yielded by the mathematical sub...
14. Figure 6.14 Typical evolution of (a) pH (along with the curve for the 45S5 Biog...
15. Figure 6.15 Formation of Ca‐P precipitates and corrosion evidences at the surfa...
16. Figure 6.16 Evolution of Raman spectra obtained from the surface of the glass G...
17. Figure 6.17 Evolution of FT‐IR spectra of the glass G‐1a over increasing immers...
18. Figure 6.18 1 × 10⁵ osteoblasts were plated in the presence of glass powders G‐...
19. Figure 6.19 Histopathological analysis in sections of bones after different tim...
20. Figure 6.20 X‐ray images before implantation (a) and (b) 2 and (c) 6 months aft...
Chapter 7
1. Figure 7.1 Double‐wall potentials curve for monoclinic and hexagonal phases. Th...
2. Figure 7.2 Hexagonal HA unit cell ordered structure. All OH groups are oriented...
3. Figure 7.3 Clusters of HA extracted from the hexagonal HA crystal model with 36...
4. Figure 7.4 Density of states (DOS) for pure HA hexagonal structure: (a) (upper ...
5. Figure 7.5 (a) a side view of the stoichiometric (001) and (101) slabs. Multipl...
6. Figure 7.6 (a)–(c) Three prototype HA surface structures. From these three mode...
7. Figure 7.7 The surface energies as a function of Ca₃(PO₄)₂ chemical potential i...
8. Figure 7.8 (a) Surface energy averaged over the entire chemical range plotted a...
9. Figure 7.9 (a) Block diagram of surface charge density measurement: 1, substrat...
10. Figure 7.10 Energy diagram for the emitting photoelectron.
11. Figure 7.11 Schematic diagram of the typical rf‐magnetron sputtering process.
12. Figure 7.12 The elemental composition of the calcium phosphate coating of 1.1 μ...
13. Figure 7.13 X‐ray diffraction pattern of an as‐deposited calcium phosphate coat...
14. Figure 7.14 The typical XRD‐patterns of as‐deposited Si‐HA coating.
15. Figure 7.15 TEM‐image of Si‐HA coating. Inset: ED‐pattern.
16. Figure 7.16 A typical HRTEM‐pattern (a) of the crystallites in Si‐HA coating (t...
17. Figure 7.17 Flow chart of the number of publications for the most studied metal...
18. Figure 7.18 Hardness (H) and Young's modulus (E) of rf‐magnetron HA coatings ve...
19. Figure 7.19 The loading–unloading (P–h) curves for Si‐HA coating and Ti substra...
20. Figure 7.20 Subcutaneous tissue state around the specimen with electrically fun...
21. Figure 7.21 Digital images of donor syngeneic bone marrow in vitro and tissue p...
22. Figure 7.22 Correlation of the tissue platelets (laminae) growth with ϕ in...
23. Figure 7.23 Histological sections of tissue laminae on the hydrogenated nanostr...
24. Figure 7.24 Histological sections of tissue platelets on the hydrogenated nanos...
Chapter 8
1. Figure 8.1 Optical images (a,c) and bright‐field TEM images of microstructure w...
2. Figure 8.2 Scheme of abc‐pressing and further rolling: 1, initial sample ...
3. Figure 8.3 Bright‐field TEM images of microstructure with microdiffraction patt...
4. Figure 8.4 Bright‐field TEM image (a) with microdiffraction pattern (b); dark‐f...
5. Figure 8.5 XRD patterns of Ti–40Nb after annealing (a) and after abc‐pressing w...
6. Figure 8.6 Tensile diagrams of Ti VT1‐0 (a) and Ti–40Nb (b) in ultrafine‐graine...
7. Figure 8.7 SEM images of the top (a–e) and cross‐sectional (f–h) CaP coatings o...
8. Figure 8.8 Plots of thickness (a, curves 1 and 2), roughness (a, curves 3 and 4...
9. Figure 8.9 XRD patterns of CaP coatings on Ti (a) and Ti–40Nb (b) deposited und...
10. Figure 8.10 IR spectra of CaP coatings on Ti deposited under different voltages...
11. Figure 8.11 Plots of Ca/P ratio for the CaP coatings on Ti (1) and Ti–40Nb (2) ...
12. Figure 8.12 Bright‐field TEM images with microdiffraction patterns for the part...
13. Figure 8.13 Plots of the glycerol and water contact angles with CaP coatings on...
14. Figure 8.14 SEM micrographs of W‐CaP coating on Ti (a–c) and Ti–40Nb (d–f) prod...
15. Figure 8.15 SEM images of cross‐sectional W‐CaP coating on Ti produced for five...
16. Figure 8.16 Plots of thickness (a,d), apparent density (b,e), and roughness (C,...
17. Figure 8.17 SEM micrograph (a) and distribution of elements (b–d) into the W–Ca...
18. Figure 8.18 XRD patterns of W–CaP coatings on Ti (a) and Ti–40Nb (b) deposited ...
19. Figure 8.19 SEM micrographs of cross‐sectional W–CaP coatings on Ti produced at...
20. Figure 8.20 Plots of thickness (a, curve 1), apparent density (a, curve 2), rou...
21. Figure 8.21 XRD patterns of W–CaP coatings on Ti produced under the voltage of ...
22. Figure 8.22 Plots of the glycerol (1, 2) and water (3, 4) contact angles with W...
23. Figure 8.23 SEM images (a,b,d,e) and XRD patterns (c,f) of Zn–CaP (a–c) and Cu–...
24. Figure 8.24 SEM images (a,b,d,e) and XRD patterns (c,f) of Zn–CaP (a–c) and Cu–...
25. Figure 8.25 Plots of thickness and roughness of Zn–CaP and Cu–CaP coatings on b...
26. Figure 8.26 IR spectra of CaP coatings on Ti (a) and Ti–40Nb (b) deposited unde...
27. Figure 8.27 Plots of glycerol and water contact angles with Zn–CaP and Cu–CaP c...
28. Figure 8.28 Phase‐contrast microscopy images of AMMSCs adhered to plastic wells...
29. Figure 8.29 TEM image of microstructure of nanostructured/ultrafine‐grained VT1...
30. Figure 8.30 Set of dental screw intraosseous implants with instruments and impl...
Chapter 9
1. Figure 9.1 Enabling technology applied in dentistry by making use of scaffold a...
Chapter 10
1. Figure 10.1 Healing of periradicular bone in case of root perforations, regardl...
2. Figure 10.2 Healing of periradicular bone in case of root perforations, in rege...
3. Figure 10.3Figure 10.3 (a) Resorption‐related perforation in right upper centra...
Chapter 11
1. Figure 11.1 A timeline representation of major points that extended our underst...
2. Figure 11.2 Schematic representation of niche dynamic reconstruction while bone...
Chapter 12
1. Figure 12.1 SEM images of TCP (a) and OCP (b) ceramic granules.
2. Figure 12.2 Rabbit parietal bone defects in different time points after implant...
3. Figure 12.3 Rabbit parietal bone defects in different time points after implant...
4. Figure 12.4 Proportions of newly formed bone tissue in the peripheral (a) and c...
5. Figure 12.5 Rabbit parietal bone defects in different time points after implant...
6. Figure 12.6 The mandible of Patient No. 1: (a) before treatment, (b) 4.5 months...
7. Figure 12.7 Patient No. 2: (a) access to the anterior lateral surface of the ma...
8. Figure 12.8 Patient No. 3: (a) CT 4.5 months after bone grafting, (b) CT after ...
9. Figure 12.9 The maxillary left sinus floor of Patient No. 3: (a) 4.5 months aft...
10. Figure 12.10 Newly formed bone tissue within the area of implanting tissue‐engi...
11. Figure 12.11 Non‐union in the mandible frontal region of Patient No. 4: (a) bef...
Chapter 13
1. Figure 13.1 Aseptic loosening of total hip prosthesis with bone defect (a) gene...
2. Figure 13.2 Clinical (a) and X‐ray aspect (b) IIIB open fracture‐dislocation of...
3. Figure 13.3 Tibial plateau fracture with depression – X‐ray and CT (a), intra‐o...
4. Figure 13.4 Posttraumatic pseudarthrosis multiply operated: X‐ray (a) shows enl...
5. Figure 13.5 Posttraumatic deformity (a) needing osteotomy with bone defect (b);...
6. Figure 13.6 Pelvic protrusion (a) with septic complication (b) followed by temp...
7. Figure 13.7 CT aspect of the calcaneal osteolysis – frontal (a), sagital (b), a...
8. Figure 13.8 Intraoperative aspect (a) and favorable outcome – radiological – sa...
9. Figure 13.9 Bilateral infected open calcaneal fracture‐preoperative X‐ray.
10. Figure 13.10 Postoperative bilateral result, with bone gap, contaminated with S...
11. Figure 13.11 Bioactive glass was used for grafting – optimal result with healin...

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Library of Congress Cataloging‐in‐Publication Data

Names: Antoniac, Iulian, editor.

Title: Bioceramics and biocomposites : from research to clinical

practice / edited by Iulian Antoniac.

Description: First edition. | Hoboken, New Jersey : John Wiley & Sons, Inc.,

[2019] | Includes bibliographical references and index. |

Identifiers: LCCN 2018056452 (print) | LCCN 2018058843 (ebook) | ISBN

9781119372134 (AdobePDF) | ISBN 9781119372141 (ePub) | ISBN 9781119049340

(hardcover : alk. paper)

Subjects: | MESH: Biocompatible Materials | Ceramics | Tissue Engineering |

Bone and Bones

Classification: LCC R857.M3 (ebook) | LCC R857.M3 (print) | NLM QT 37 | DDC

610.28–dc23

LC record available at https://lccn.loc.gov/2018056452

Cover Design: Wiley

Cover Image: © danielzgombic/Getty Images

List of Contributors

Simeon Agathopoulos

Materials Science and Engineering Department,

University of Ioannina,

Ioannina, Greece

Ika D. Ana

Department of Dental Biomedical Sciences,

Faculty of Dentistry,

Universitas Gadjah Mada,

Yogyakarta 55281, Indonesia

Maidaniuc Andreea

Department of Metallic Materials Science,

Physical Metallurgy,

Faculty of Material Science and Engineering,

Politehnica University of Bucharest,

Bucharest, Romania

Ilia Y. Bozo

Human Stem Cells Institute,

Moscow, Russia

A.I. Evdokimov Moscow State University of Medicine and Dentistry,

Moscow, Russia

A.I. Burnazyan Federal Medical and Biophysical Center,

Moscow, Russia

Vladimir Bystrov

Institute of Mathematical Problems of Biology,

Keldysh Institute of Applied Mathematics,

Russian Academy of Sciences,

142290, Pushchino, Russia

Anna Bystrova

Institute of Biomedical Engineering and Nanotechnologies,

Riga Technical University,

Riga, Latvia

Mocanu A. Cătălina

Department of Metallic Materials Science,

Physical Metallurgy,

Faculty of Material Science and Engineering,

Politehnica University of Bucharest,

Bucharest, Romania

Daniel Chappard

GEROM Groupe Etudes Remodelage Osseux et bioMatériaux – NextBone and SCIAM,

Service Commun d'Imagerie et Analyses Microscopiques,

Institut de Biologie en Santé,

CHU d'Angers,

Université d'Angers,

49933 Angers Cedex, France

Roman V. Deev

Human Stem Cells Institute,

Moscow, Russia

A.I. Burnazyan Federal Medical and Biophysical Center,

Moscow, Russia

Kazan (Volga region) Federal University,

Kazan, Russia

Yuri Dekhtyar

Institute of Biomedical Engineering and Nanotechnologies,

Riga Technical University,

Riga, Latvia

Petr S. Eremin

A.I. Burnazyan Federal Medical and Biophysical Center,

Moscow, Russia

Ilya I. Eremin

A.I. Burnazyan Federal Medical and Biophysical Center,

Moscow, Russia

Anna Eroshenko

Institute of Strength Physics and Materials Science SB RAS,

2/4 Akademicheskii prospekt, Tomsk, 634055 Russia

Miculescu Florin

Department of Metallic Materials Science,

Physical Metallurgy,

Faculty of Material Science and Engineering,

Politehnica University of Bucharest,

Bucharest, Romania

Stan E. George

Laboratory of Multifunctional Materials and Structures,

National Institute of Materials Physics,

Măgurele‐Bucharest, Romania

Irina M. Gheorghiu

Department of Endodontology,

“Carol Davila” University of Medicine and Pharmacy,

Bucharest, Romania

Vasily I. Grachev

X‐ray Diagnostics Laboratories “3D Lab”,

Moscow, Russia

Sri Hinduja

The University of Manchester,

School of Mechanical, Aerospace and Civil Engineering,

Manchester, United Kingdom

Boyang Huang

The University of Manchester,

School of Mechanical,

Aerospace and Civil Engineering,

Manchester,

United Kingdom

Alexandru A. Iliescu

Department of Oral Rehabilitation,

University of Medicine and Pharmacy of Craiova,

Craiova, Romania

Mihaela G. Iliescu

Department of Endodontology,

“Carol Davila” University of Medicine and Pharmacy,

Bucharest, Romania

Voicu S. Ioan

Department of Analytical Chemistry and Environmental Engineering,

Faculty of Applied Chemistry and Material Science,

Politehnica University of Bucharest,

Bucharest, Romania

Iulian Antoniac

Department of Metallic Materials Science,

Physical Metallurgy,

Faculty of Material Science and Engineering,

Politehnica University of Bucharest,

313 Splaiul Independentei, District 6, JA 104‐106 Building, 060042 Bucharest, Romania

Igor A. Khlusov

Department of Morphology and General Pathology,

Siberian State Medical University,

634050, Tomsk, Russia

National Research Tomsk Polytechnic University,

Research School of Chemistry & Applied Biomedical Sciences,

634050, Tomsk, Russia

Marina Yu. Khlusova

Department of Morphology and General Pathology,

Siberian State Medical University,

634050, Tomsk, Russia

National Research Tomsk Polytechnic University,

Research School of Chemistry & Applied Biomedical Sciences,

634050, Tomsk, Russia

Ekaterina Komarova

Institute of Strength Physics and Materials Science SB RAS,

2/4 Akademicheskii prospekt, Tomsk, 634055 Russia

Vladimir S. Komlev

A.A. Baikov Institute of Metallurgy and Materials Science,

Russian Academy of Sciences,

Moscow, Russia

Institute of Laser and Information Technologies,

Russian Academy of Sciences,

Moscow, Russia

Larisa Litvinova

Laboratory of Immunology and Cellular Biotechnology,

Immanuel Kant Baltic Federal University,

14 A. Nevskogo Street, 236041 Kaliningrad, Russia

Fengyuan Liu

The University of Manchester,

School of Mechanical, Aerospace and Civil Engineering,

Manchester, United Kingdom

Horia O. Manolea

Department of Oral Rehabilitation,

University of Medicine and Pharmacy of Craiova,

Craiova, Romania

Miculescu Marian

Department of Metallic Materials Science,

Physical Metallurgy,

Faculty of Material Science and Engineering,

Politehnica University of Bucharest,

Bucharest, Romania

Gujie Mi

Department of Chemical Engineering,

Northeastern University,

Boston, MA 02115, USA

Lupescu Olivera

Department of Orthopaedics,

Faculty of Medicine,

“Carol Davila” University of Medicine and Pharmacy of Bucharest,

37 Dionisie Lupu Street, District 2, 020021 Bucharest, Romania

Paola Palmero

Department of Applied Science and Technology,

INSTM R.U. PoliTO,

LINCE Laboratory,

Politecnico di Torino,

Corso Duca degli Abruzzi, 24, 10129 Torino, Italy

Paula Perlea

Department of Endodontology,

“Carol Davila” University of Medicine and Pharmacy,

Bucharest, Romania

Vladimir Pichugin

National Research Tomsk Polytechnic University,

Research School of Chemistry & Applied Biomedical Sciences,

634050, Tomsk, Russia

Konstantin Prosolov

National Research Tomsk Polytechnic University,

Research School of High‐Energy Physics,

634050, Tomsk, Russia

Institute of Strength Physics and Materials Science of SB RAS,

Russia

Andrey A. Pulin

A.I. Burnazyan Federal Medical and Biophysical Center,

Moscow, Russia

Sergey I. Rozhkov

A.I. Evdokimov Moscow State University of Medicine and Dentistry,

Moscow, Russia

Maria Sedelnikova

Institute of Strength Physics and Materials Science SB RAS,

2/4 Akademicheskii prospekt, Tomsk, 634055 Russia

Yurii Sharkeev

National Research Tomsk Polytechnic University,

Research School of High‐Energy Physics,

634050, Tomsk, Russia

Institute of Strength Physics and Materials Science of SB RAS,

Russia

Di Shi

Department of Chemical Engineering,

Northeastern University,

Boston, MA 02115, USA

Valeria Shupletsova

Laboratory of Immunology and Cellular Biotechnology,

Immanuel Kant Baltic Federal University,

14 A. Nevskogo Street, 236041 Kaliningrad, Russia

Paulo J. da Silva Bartolo

The University of Manchester,

School of Mechanical, Aerospace and Civil Engineering,

Manchester, United Kingdom

Izabela‐Cristina Stancu

APMG Advanced Polymer Materials Group,

Faculty of Applied Chemistry and Materials Science,

Faculty of Medical Engineering,

University Politehnica of Bucharest,

1–7 Gh Polizu Street, Sector 1, 011061 Bucharest, Romania

Evgeniy N. Toropov

A.I. Burnazyan Federal Medical and Biophysical Center,

Moscow, Russia

Gabriel Tulus

European Society of Endodontology,

Viersen, Germany

Dilshat U. Tulyaganov

Turin Polytechnic University in Tashkent,

Niyazova, Uzbekistan

Grigory A. Volozhin

A.I. Evdokimov Moscow State University of Medicine and Dentistry,

Moscow, Russia

Thomas J. Webster

Department of Chemical Engineering,

Northeastern University,

Boston, MA 02115, USA

Center of Excellence for Advanced Materials Research,

King Abdulaziz University,

Jeddah, Saudi Arabia

Vadim L. Zorin

Human Stem Cells Institute,

Moscow, Russia

A.I. Burnazyan Federal Medical and Biophysical Center,

Moscow, Russia

Bioceramics and Biocomposites

From Research to Clinical Practice

Copyright

List of Contributors